internal ribosome entry pathway
| PAG Title | internal ribosome entry pathway |
| PAG ID | WAG001034 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | Control of translation is one of the major regulatory events in eukaryotic gene expression. Interl ribosome entry sites (IRES) were first discovered in picorvirus Rs but it is now clear that IRESs are also present in the 5?untranslated region of many eukaryotic genes including those encoding: growth factors e.g. VEGF, FGF2 and PDGF; genes whose protein products are associated with apoptosis e.g. Apaf-1, IXAP;transcription factors e.g. c- myc; the potassium channel Kv1.4. IRES allows the ribosomes to be recruited to an initiator AUG, which is some distance from the 5' end of the message R to bypass the Kozak scanning mechanism.. In the Kozak scanning model, the 40S ribosomal subunit bearing Met-tRmet and initiation factors, binds near the capped 5¿d of the mR and travels along the mR until it comes to the first AUG. |
| Species | Homo sapiens |
| nCoCo Score | 1,745 |
| Base PAG ID | WAG001034 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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